京都大学医学研究科人間健康科学系専攻 分子生命基礎医療科学分野 野中研究室

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研究業績

原著論文（査読あり）

  1. Higashi K, Oda S, Fujii M, Nishida F, Matsumoto H, Morise J, Oka S, Nonaka M. (2023) Construction of a T7 phage random peptide library by combining seamless cloning with in vitro translation. Journal of biochemistry, 175, 85-93.
  2. Aoki, K., Manabe, A., Kimura, H., Katoh, Y., Inuki, S., Ohno, H., Nonaka, M., and Oishi, S. (2023) Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold. Bioconjug. Chem. 34, 2055–2065.
  3. Iwamoto, N., Sato, Y., Manabe, A., Inuki, S., Ohno, H., Nonaka, M., and Oishi, S. (2023) Design and Synthesis of Monobody Variants with Low Immunogenicity. ACS Med. Chem. Lett. 14, 1596–1601.
  4. Nakao, H., Yamaguchi, T., Kawabata, K., Higashi, K., Nonaka, M., Tuiji, M., Nagai, Y., Toyoda, H., Yamaguchi, Y., Kawasaki, N., and Kawasaki, T. (2022) Characterization of Novel Antibodies that Recognize Sialylated Keratan Sulfate and Lacto-N-fucopentaose I on Human Induced Pluripotent Cells: Comparison with Existing Antibodies. Glycobiology. 33, 150
  5. Matsuda, T., Misato, K., Tamiya, S., Akeda, Y., Nakase, I., Kuroda, E., Takahama, S., Nonaka, M., Yamamoto, T., Fukuda, M. N., and Yoshioka, Y. (2022) Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice. iScience. 25, 105324
  6. Yoneyama, T., Hatakeyama, S., Sutoh Yoneyama, M., Yoshiya, T., Uemura, T., Ishizu, T., Suzuki, M., Hachinohe, S., Ishiyama, S., Nonaka, M., Fukuda, M. N., and Ohyama, C. (2021) Correction to: Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy. BMC Cancer. 21, 105
  7. Yoneyama, T., Hatakeyama, S., Sutoh Yoneyama, M., Yoshiya, T., Uemura, T., Ishizu, T., Suzuki, M., Hachinohe, S., Ishiyama, S., Nonaka, M., Fukuda, M. N., and Ohyama, C. (2021) Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy. BMC Cancer. 21, 72
  8. Nonaka, M., Mabashi-Asazuma, H., Jarvis, D. L., Yamasaki, K., Akama, T. O., Nagaoka, M., Sasai, T., Kimura-Takagi, I., Suwa, Y., Yaegashi, T., Huang, C.-T., Nishizawa-Harada, C., and Fukuda, M. N. (2021) Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides. PLoS One. 16, e0241157
  9. Nonaka, M., Suzuki-Anekoji, M., Nakayama, J., Mabashi-Asazuma, H., Jarvis, D. L., Yeh, J.-C., Yamasaki, K., Akama, T. O., Huang, C.-T., Campos, A. R., Nagaoka, M., Sasai, T., Kimura-Takagi, I., Suwa, Y., Yaegashi, T., Shibata, T. K., Sugihara, K., Nishizawa-Harada, C., Fukuda, M., and Fukuda, M. N. (2020) Overcoming the blood-brain barrier by Annexin A1-binding peptide to target brain tumours. Br. J. Cancer. 123, 1633–1643
  10. Morise, J., Yamamoto, S., Midorikawa, R., Takamiya, K., Nonaka, M., Takematsu, H., and Oka, S. (2020) Distinct Cell Surface Expression Patterns of N-Glycosylation Site Mutants of AMPA-Type Glutamate Receptor under the Homo-Oligomeric Expression Conditions. Int. J. Mol. Sci. 10.3390/ijms21145101
  11. Nonaka, M., Matsumoto, S., Ma, B. Y., Kido, H., Kawasaki, N., Kawasaki, N., and Kawasaki, T. (2020) Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells. Appl. Sci. 10, 2687
  12. Matsumoto, S., Nakao, H., Kawabe, K., Nonaka, M., Toyoda, H., Takishima, Y., Kawabata, K., Yamaguchi, T., Furue, M. K., Taki, T., Okumura, T., Yamazaki, Y., Nakaya, S., Kawasaki, N., and Kawasaki, T. (2015) A Cytotoxic Antibody Recognizing Lacto-N-fucopentaose I (LNFP I) on Human Induced Pluripotent Stem (hiPS) Cells. J. Biol. Chem. 290, 20071–20085
  13. Nonaka, M., Fukuda, M. N., Gao, C., Li, Z., Zhang, H., Greene, M. I., Peehl, D. M., Feizi, T., and Fukuda, M. (2014) Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes. J. Biol. Chem. 289, 16478–16486
  14. Gao, C., Liu, Y., Zhang, H., Zhang, Y., Fukuda, M. N., Palma, A. S., Kozak, R. P., Childs, R. A., Nonaka, M., Li, Z., Siegel, D. L., Hanfland, P., Peehl, D. M., Chai, W., Greene, M. I., and Feizi, T. (2014) Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array. J. Biol. Chem. 289, 16462–16477
  15. Nonaka, M., Bao, X., Matsumura, F., Götze, S., Kandasamy, J., Kononov, A., Broide, D. H., Nakayama, J., Seeberger, P. H., and Fukuda, M. (2014) Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. Proc. Natl. Acad. Sci. U. S. A. 111, 8173–8178
  16. Nonaka, M., Imaeda, H., Matsumoto, S., Yong Ma, B., Kawasaki, N., Mekata, E., Andoh, A., Saito, Y., Tani, T., Fujiyama, Y., and Kawasaki, T. (2014) Mannan-binding protein, a C-type serum lectin, recognizes primary colorectal carcinomas through tumor-associated Lewis glycans. J. Immunol. 192, 1294–1301
  17. Kawabe, K., Tateyama, D., Toyoda, H., Kawasaki, N., Hashii, N., Nakao, H., Matsumoto, S., Nonaka, M., Matsumura, H., Hirose, Y., Morita, A., Katayama, M., Sakuma, M., Kawasaki, N., Furue, M. K., and Kawasaki, T. (2013) A novel antibody for human induced pluripotent stem cells and embryonic stem cells recognizes a type of keratan sulfate lacking oversulfated structures. Glycobiology. 23, 322–336
  18. Nonaka, M., Ma, B. Y., Imaeda, H., Kawabe, K., Kawasaki, N., Hodohara, K., Kawasaki, N., Andoh, A., Fujiyama, Y., and Kawasaki, T. (2011) Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas. J. Biol. Chem. 286, 22403–22413
  19. Nakamura, N., Nonaka, M., Ma, B. Y., Matsumoto, S., Kawasaki, N., Asano, S., and Kawasaki, T. (2009) Characterization of the interaction between serum mannan-binding protein and nucleic acid ligands. J. Leukoc. Biol. 86, 737–748
  20. Ma, B. Y., Yoshida, K., Baba, M., Nonaka, M., Matsumoto, S., Kawasaki, N., Asano, S., and Kawasaki, T. (2009) The lectin Jacalin induces human B-lymphocyte apoptosis through glycosylation-dependent interaction with CD45. Immunology. 127, 477–488
  21. Nonaka, M., Ma, B. Y., Murai, R., Nakamura, N., Baba, M., Kawasaki, N., Hodohara, K., Asano, S., and Kawasaki, T. (2008) Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells. J. Immunol. 180, 3347–3356
  22. Ma, B. Y., Kaihama, M., Nonaka, M., Oka, S., Kawasaki, N., and Kawasaki, T. (2007) LPS suppresses expression of asialoglycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages. Glycoconj. J. 24, 243–249
  23. Nonaka, M., Ma, B. Y., Ohtani, M., Yamamoto, A., Murata, M., Totani, K., Ito, Y., Miwa, K., Nogami, W., Kawasaki, N., and Kawasaki, T. (2007) Subcellular localization and physiological significance of intracellular mannan-binding protein. J. Biol. Chem. 282, 17908–17920
  24. Ma, B. Y., Nakamura, N., Dlabac, V., Naito, H., Yamaguchi, S., Ishikawa, M., Nonaka, M., Ishiguro, M., Kawasaki, N., Oka, S., and Kawasaki, T. (2007) Isolation, cloning, and characterization of a novel phosphomannan-binding lectin from porcine serum. J. Biol. Chem. 282, 12963–12975
  25. Baba, M., Yong Ma, B., Nonaka, M., Matsuishi, Y., Hirano, M., Nakamura, N., Kawasaki, N., Kawasaki, N., and Kawasaki, T. (2007) Glycosylation-dependent interaction of Jacalin with CD45 induces T lymphocyte activation and Th1/Th2 cytokine secretion. J. Leukoc. Biol. 81, 1002–1011

総説・書籍

  1. 野中元裕（2024）糖鎖模倣ペプチドの取得と主要標的能を利用した治療法への応用、生化学、96 (2) 184-191.
  2. Nonaka, M. (2021) Carbohydrate Mimetic Peptides as Anti-Cancer Therapeutics. Trends Glycosci. Glycotechnol. 33, E1–E4
  3. Kajihara, Y., Yamamoto, K., Satoh, M., Manabe, S., Oda, T., Shimomura, O., Tateno, H., Hirabayashi, J., Sakurai, K., Miyagawa, S., Tanaka, K., Fukuda, M. N., and Nonaka, M. (2019) Glycoengineering. in Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG) (Taniguchi, N., Endo, T., Hirabayashi, J., Nishihara, S., Kadomatsu, K., Akiyoshi, K., and Aoki-Kinoshita, K. F. eds), pp. 145–166, Springer Singapore, Singapore
  4. 野中元裕（2017）『「IBD免疫の更なる理解をめざして!」（IBD病態理解に役立つ糖鎖機能の基礎）』、IBD Research 11(1) 7-12
  5. Nonaka, M. (2016) Function of the glycosyltransferase GnT-V in colitis. J. Gastroenterol. 51, 406–408
  6. Nonaka, M., and Fukuda, M. (2016) Expression and Function of Poly-N-Acetyllactosamine Type Glycans in Cancer. in Glycosignals in Cancer: Mechanisms of Malignant Phenotypes (Furukawa, K., and Fukuda, M. eds), pp. 141–161, Springer Japan, Tokyo
  7. Kawasaki, T., Nonaka, M., and Kawasaki, N. (2015) Mannan-Binding Protein (MBP)-Ligand Glycans: Novel Tissue MarkerTissue tumor markerfor Colorectal Carcinomas. in Glycoscience: Biology and Medicine (Taniguchi, N., Endo, T., Hart, G. W., Seeberger, P. H., and Wong, C.-H. eds), pp. 1021–1028, Springer Japan, Tokyo
  8. Nonaka, M., and Kawasaki, T. (2014) Functional Assay Using Lectin Gene Targeting Technologies (Over-Expression). in Lectins: Methods and Protocols (Hirabayashi, J. ed), pp. 389–399, Springer New York, New York, NY
  9. Nonaka, M., and Fukuda, M. (2012) Galectin-1 for neuroprotection? Immunity. 37, 187–189
  10. Nonaka, M., Ma, B. Y., and Kaswasaki, T. (2009) 樹状細胞上の C 型レクチン DC-SIGN による結腸がん細胞表面糖鎖の認識と腫瘍免疫の制御. Trends Glycosci. Glycotechnol. 21, 228–236
  11. 野中元裕、B. Y. Ma、川嵜敏祐（2009）『「ますます重要になる細胞周辺環境（細胞ニッチ）の最新科学技術」（糖鎖認識レセプターによる糖鎖シグナルの制御）』、遺伝子医学MOOK別冊257-262頁、メディカルドゥ
  12. 野中元裕、Bruce Yong Ma、川嵜敏祐（2008）『「糖鎖情報の独自性と普遍性」（樹状細胞レクチンによる糖鎖認識と免疫調節）』、蛋白質核酸酵素 増刊 1649-1654頁、共立出版